Forget Eylea: Regeneron's Real Value May Be Hiding in Its Dupixent Profit Share

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Regeneron Pharmaceuticals has lagged behind the broader market over the past two years, primarily due to declining sales of its flagship eye treatment, Eylea. Facing fierce competition from biosimilars and alternative therapies, the combined U.S. revenue for both the original and newer high-dose formulations fell 12% year over year to approximately $1 billion. Fortunately, the company's collaboration asset with Sanofi, Dupixent, continues to deliver remarkable growth, acting as a vital buffer against these headwinds. Global sales for Dupixent surged 38% year over year to $6 billion, driving Regeneron's partnership revenue up 51% to $2.2 billion. This stellar performance enabled Regeneron to post a strong second-quarter financial update, with total revenue rising 17% to $4.3 billion and non-GAAP net income per share climbing 11% to $14.29, demonstrating robust underlying business strength.

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Despite declining sales of the eye disease treatment Eylea, Regeneron's Q2 revenue increased by 17% year-over-year to $4.3 billion, driven by strong growth in Dupixent. Global sales of Dupixent surged by 38%, offsetting the company's sluggish performance and establishing itself as a core growth driver. Investors need to pay attention to Dupixent's profit-sharing revenue despite the risk of intensifying competition for Eylea.

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Regeneron successfully overcame the negative impact of a 12% decline in U.S. Eylea sales as global sales of Dupixent, co-developed with Sanofi, reached $6.0 billion and collaboration revenue surged by 51%. Non-GAAP earnings per share (EPS) also rose 11% to $14.29, proving solid fundamentals.

If Dupixent continues its high growth driven by expanded indications such as COPD and asthma, the stock price can recover its upward momentum. On the other hand, if the offensive of Eylea biosimilars turns out stronger than expected, profit margin pressure will act as a risk factor, requiring close monitoring of quarterly prescription data and collaboration profit margins.

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